Online social networking facilitates collegial communication among registered nurses and provides convenient and timely forums for professional development and education. It also presents remarkable potential for public education and health guidance, contributing to nursing’s online professional presence. At the same time, the inherent nature of social networking invites the sharing of personal information or work experiences that may reflect poorly on a nurse’s professionalism. ANA’s Principles for Social Networking and the Nurse: Guidance for the Registered Nurse provides guidance to registered nurses on using social networking media in a way that protects patients’ privacy and confidentiality and maintains the standards of professional nursing practice. These six essential principles are relevant to all registered nurses and nursing students across all roles and settings.